Protection of ischemic/reperfused canine myocardium by CL18/6, a monoclonal antibody to adhesion molecule ICAM-1 - Concepedia

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Protection of ischemic/reperfused canine myocardium by CL18/6, a monoclonal antibody to adhesion molecule ICAM-1

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References

1995

Year

Joseph C. Hartman, D C Anderson, Ann L. Wiltse, C L Lane, C L Rosenbloom, Alex Manning, William R. Humphrey, Terrahn Wall, Ronald J. Shebuski

Cardiovascular Research

Abstract

The results indicate that CL18/6 antagonism of ICAM-1 provided cardioprotection associated with reduced neutrophil activity in vulnerable myocardium, and suggest that ICAM-1 mediated neutrophil sequestration in endangered cardiac tissue is an important mechanism of myocardial ischemia/reperfusion injury.