Efficient Synthesis of Pyrazoles: Oxidative CC/NN Bond‐Formation Cascade

Abstract

Golden section: A novel synthetic strategy for the synthesis of tetrasubstituted pyrazoles is provided. In an efficient CC/NN bond-formation cascade, enamines and nitriles are oxidatively coupled to deliver pyrazoles in good yields (see scheme). The ready availability of the starting materials, the high level of practicability of the reaction and work up, and the avoidance of hydrazine starting materials make the method attractive. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.