Body Mass Index Differences in Pseudohypoparathyroidism Type 1a<i>Versus</i>Pseudopseudohypoparathyroidism May Implicate Paternal Imprinting of Gαs in the Development of Human Obesity

Abstract

Although the AHO phenotype for PHP1a and pseudoPHP has been thought to be similar, we have found that obesity is a more prominent feature in PHP1a than in pseudoPHP and that severe obesity is characteristic of PHP1a specifically. These findings may implicate paternal imprinting of Galpha(s) in the development of human obesity.