Acute Hemodynamic Effects of Conivaptan, a Dual V _1A and V ₂ Vasopressin Receptor Antagonist, in Patients With Advanced Heart Failure

Abstract

In patients with advanced heart failure, vasopressin receptor antagonism with conivaptan resulted in favorable changes in hemodynamics and urine output without affecting blood pressure or heart rate. These data suggest that vasopressin is functionally significant in advanced heart failure and that further investigations are warranted to examine the effects of conivaptan on symptom relief and natural history in such patients.