The tethered agonist approach to mapping ion channel proteins – toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor

Ionic channels of excitable membranes

General Pharmacology The Vascular System · 1985 · 7K citations

Natural Sciences, Biochemistry, Biophysics +14

Atomic Structure of Acetylcholinesterase from <i>Torpedo californica</i> : A Prototypic Acetylcholine-Binding Protein

Joel L. Sussman, Michal Harel, Felix Frolow et al. · Science · 1991 · 2.7K citations

Life Sciences, Biochemistry, Molecular Biology +17

A General Method for Site-specific Incorporation of Unnatural Amino Acids into Proteins

Christopher J. Noren, Spencer J. Anthony‐Cahill, Michael Griffith et al. · Science · 1989 · 1K citations

Life Sciences, Biochemistry, Molecular Biology +14

Acetylcholine Binding by a Synthetic Receptor: Implications for Biological Recognition

Dennis A. Dougherty, David A. Stauffer · Science · 1990 · 620 citations

Medicine, Biochemistry, Pharmacology +17

From <i>ab initio</i> quantum mechanics to molecular neurobiology: A cation–π binding site in the nicotinic receptor

Wenge Zhong, Justin P. Gallivan, Yinong Zhang et al. · Proceedings of the National Academy of Sciences · 1998 · 550 citations · Full text

Medicine, Biochemistry, Neurobiology +17