Concepedia

Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma.

Joseph Kwong, Kwok Wai Lo, Ka‐Fai To, Peter M.L. Teo, Philip E. Johnson, Dolly P. Huang

PubMed · 2002 · 257 citations · 45 references

Abstract

A high frequency of aberrant methylation of the 5' CpG island of the RASSF1A, RARbeta2, DAP-kinase, and p16 genes in the present study was noted. Our findings suggest that methylation of the genes in the critical pathways is common in NPC.

References

45

Glutathione S-Transferases

William H. Habig, M. Pabst, William B. Jakoby · Journal of Biological Chemistry · 1974 · 17.9K citations · Full text

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

James G. Herman, Jeremy R. Graff, Sanna Myöhänen et al. · Proceedings of the National Academy of Sciences · 1996 · 5.6K citations · Full text

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

Manuel Serrano, Gregory J. Hannon, David Beach · Nature · 1993 · 3.7K citations

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Inactivation of the DNA-Repair Gene<i>MGMT</i>and the Clinical Response of Gliomas to Alkylating Agents

Manel Esteller, Jesús García‐Foncillas, Esther Andion et al. · New England Journal of Medicine · 2000 · 2.2K citations · Full text

A gene hypermethylation profile of human cancer.

Manel Esteller, Paul G. Corn, Stephen B. Baylin et al. · PubMed · 2001 · 2K citations

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