2′‐SCF₃ Uridine—A Powerful Label for Probing Structure and Function of RNA by ¹⁹F NMR Spectroscopy

Abstract

Fluorishing: the Togni reagent allows efficient synthetic access to fluorine-labeled RNA molecules. These are in turn highly useful for NMR spectroscopic analyses of secondary and tertiary structures, RNA-protein interactions, and functionality of riboswitch modules.