Physiological Reviews · 1957 · 18 citations · 0 references
Life SciencesCell BiologyPhysiologyAgingPathophysiologyPhysical ActivityFatiguePhysiological Disorders
EE PURPOSE of the present review is not to produce an exhaustive compilation of the work done in the area, but rather to state the relation of the various phenomena of inadequacy to each other according to some integrating scheme. Since the phenomena that have been called fatigue pertain not only to cell function and to tissues but also the the organism as a whole, several academic dis-ciplines are generally involved. Furthermore, it has not always been clear in what ways they are involved. Inadequacy. For every system, be it a cell, a tissue, or the organism as a whole, there are certain kinds and ranges of activity that are considered normal and ade-quate. There are also certain kinds of processes that are inadequate as judged from one or another point of view. Thus the term ‘inadequacy ’ is a perfectly good generic term and forms an appropriate place to begin our general discussion. The term, ‘fatigue, ’ arose first not as a technical physiological term but in common conversation to label a self-realized state of human inadequacy symptom-at&d in discomfort, realization of productive incapacity, the feeling of weakness