Convergent Synthesis of Triazole Dendrimers via Click Chemistry Using Tripodal Core

Abstract

Azides and alkynes are among the least reactive functional groups and normally require prolonged heating to form the cycloaddition product. Recent investigation of the click chemistry, the Cu(I)-catalyzed Huisgen [2 + 3] dipolar cycloaddition reaction between an organic azide and an alkyne, has attracted attention.1 The reaction, characterized by very high yields, mild and simple reaction conditions, oxygen and water tolerance, and simple ways to product isolations, is highly chemoselective affording only the desired 1,2,3-triazole even in the presence of a large variety of other functional groups. The methodology has found many applications in organic chemistry,2 supramolecular chemistry,3 drug discovery,4 bioconjugations,5 and materials science.6 Dendrimers are highly branched macromolecules, which