Journal of Feline Medicine and Surgery · 2010 · 112 citations · 70 references
MedicinePharmacologyVeterinary PharmacologyClinical PharmacologyPain ManagementPain MedicineAnalgesiaAnalgesic PharmacologyNon-opioid AnalgesicsOpioid PharmacologyVeterinary Pain ManagementAnalgesic Drug MechanismsAntipyretic TherapyFeline Pain ManagementLong-term Medication UseNsaid TherapySerious Adverse Drug ReactionsTherapeutic MechanismsVeterinary Analgesia
UNLABELLED: NSAIDS AND CATS: Non-steroidal anti-inflammatory drugs (NSAIDs) are an important class of drug in feline medicine, having analgesic, anti-inflammatory and antipyretic activity. While most published data on their use in this species relate to short-term (often perioperative) therapy, there is increasing evidence of the value of these drugs in treating chronic pain in cats (for example, that associated with degenerative joint disease), and some NSAIDs have now become licensed for long-term use in cats in some geographies. Most of our knowledge of therapeutic mechanisms or adverse drug reactions associated with NSAIDs is extrapolated from work in other species, and there is a paucity of published data relating to cats. GUIDELINES: These guidelines have been drawn together by an expert panel, which have reviewed the current literature on long-term NSAID use in cats and other species, and developed guidance on their use based on this information. The aim is to provide practical information for veterinarians to encourage appropriate NSAID therapy whenever cats will benefit from the use of these drugs.
70
COX-1 and COX-2 tissue expression: implications and predictions.
Crofford Lj · PubMed · 1997 · 680 citations
NSAID Use and Progression of Chronic Kidney Disease
Katherine Gooch, Bruce F. Culleton, Braden Manns et al. · The American Journal of Medicine · 2007 · 336 citations · Full text