NLRP3 inflammasome–mediated neutrophil recruitment and hypernociception depend on leukotriene B₄in a murine model of gout

Abstract

These results reveal the role of the NLRP3 inflammasome in mediating MSU crystal-induced inflammation and dysfunction of the joints, and highlight a previously unrecognized role of LTB(4) in driving NLRP3 inflammasome activation in response to MSU crystals, both in vitro and in vivo.