The Laboratory Diagnosis of Haemophilia

Abstract

first showed that, when haemo- philic blood clotted, the consumption of prothrombin was less than normal, and this has since been confirmed (Quick, 1947; Soulier, 1948; Alexander and de Vries, 1949; Merskey, 1950a). Prothrombin consumption can be measured on the serum from whole clotted blood, obtained by venepuncture or finger-prick, or on that obtained by recalcifying citrated plasma.