Chiral Iridium Catalysts Bearing Spiro Pyridine‐Aminophosphine Ligands Enable Highly Efficient Asymmetric Hydrogenation of β<i>‐</i>Aryl β‐Ketoesters

Abstract

Tons of TONs: Chiral iridium catalysts bearing ligand 1 are highly efficient for the asymmetric hydrogenation of β-substituted β-ketoesters. The product β-hydroxyesters are delivered in high yield with excellent enantioselectivities and high turnover numbers (TONs). cod= 1,5-cyclooctadiene.