Infection and Immunity · 2002 · 99 citations · 18 references
Veterinary MedicineImmunologyInfectious DiseasesHost-pathogen InteractionsImmunology Of Infectious DiseasesVaccinologyBacterial InfectionsHost Defense Against InfectionImmune Responses To InfectionRodent Infectious DiseasesVaccinationBiological AerosolsMurine Models
A whole-body mouse model of pneumonic melioidosis was established for future evaluation of biodefense vaccine candidates. The aerosol 50% lethal doses of Burkholderia pseudomallei strain 1026b for BALB/c and C57BL/6 mice and the times to death, dissemination in organs, and tissue loads after exposure of the mice to low- and high-dose aerosols are reported. In addition, rpsL mutant backgrounds were attenuated in this acute model of disease.
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A simple method of estimating 50 per cent end points
Hr Muench · Medical Entomology and Zoology · 1938 · 8.4K citations
Eiko Yabuuchi, Yoshimasa Kosako, Hiroshi Oyaizu et al. · Microbiology and Immunology · 1992 · 931 citations · Full text
Life Sciences, Biology, Microbiology +12