A Study to Evaluate the Efficacy of Various Topical Treatment Modalities for Alopecia Areata

Abstract

CONTEXT: Alopecia Areata (AA) is a common form of non-scarring hair disorder of unclear etiology. The disease may have serious psychological effect. AIMS: The objective is to assess the therapeutic effect and side effects of various topical modalities for the treatment of AA. SETTINGS AND DESIGN: Open, randomized, comparative study. MATERIALS AND METHODS: For this study, 30 patients were included of all age groups and both sexes having localized (<5 patches and <25% scalp involvement) alopecia, with no underlying disease or family history, and who had not received any treatment before. They were treated sequentially with 5 different combination regimes for 3 months. The response was assessed subjectively as well as objectively by the "Severity of Alopecia Tool Score". STATISTICAL ANALYSIS: Chi-square test. RESULTS: Out of the 5 modalities studied, the Intralesional and Topical Steroids were the most effective with no significant side effects. CONCLUSIONS: Among the various topical modalities used for the treatment of AA, the most effective are the Intralesional and Topical steroids with no significant side-effects.