Science · 2003 · 2.8K citations · 17 references
Life SciencesGeneticsNeuroscienceMolecular NeurobiologyMolecular NeuroscienceNeurodegenerationMolecular Basis Of NeurodegenerationMolecular NeurogeneticsNeurodegenerative DiseasesNeurodegenerative DisordersParkinson DiseaseParkinsonian DisordersCellular Oxidative Stress ResponseMonogenic SyndromesNeurodegeneration GeneticsOxidative Stress In NeurodegenerationOxidative Stress Response PathwaysParkinson's Disease GeneticsParkinsonian DegenerationProtein Oxidation In Neurodegeneration
The DJ‑1 gene encodes a ubiquitous, highly conserved protein whose function is largely unknown but is implicated in the oxidative stress response. The study aims to link DJ‑1 mutations to PARK7 parkinsonism and to elucidate DJ‑1’s role in neuronal maintenance and Parkinson’s disease pathogenesis. Loss of DJ‑1 function causes neurodegeneration.
The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism. The function of the DJ-1 protein remains unknown, but evidence suggests its involvement in the oxidative stress response. Our findings indicate that loss of DJ-1 function leads to neurodegeneration. Elucidating the physiological role of DJ-1 protein may promote understanding of the mechanisms of brain neuronal maintenance and pathogenesis of Parkinson's disease.
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WHAT IF: A molecular modeling and drug design program
Gert Vriend · Journal of Molecular Graphics · 1990 · 3.5K citations
Twilight zone of protein sequence alignments
Burkhard Rost · Protein Engineering Design and Selection · 1999 · 1.9K citations