Quadruple Domino Organocatalysis: An Asymmetric Aza‐Michael/Michael/Michael/Aldol Reaction Sequence Leading to Tetracyclic Indole Structures with Six Stereocenters

Abstract

Quadruple domino/Wittig–one pot: An organocatalytic, asymmetric, three-component quadruple cascade, which leads to tetracyclic double-annulated indole derivatives, is described. The domino products were further derivatized by aldehyde olefination under one-pot conditions to obtain complex isoindolo[2, 1-a]indole derivatives bearing six stereogenic centers in a highly stereoselective fashion. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.