Publication | Closed Access
Studies Towards the Total Synthesis of Epothilones: Asymmetric Synthesis of the Key Fragments
71
Citations
20
References
1996
Year
Bioorganic ChemistryEngineeringOrganic ChemistryChemistryChemical BiologyAsymmetric SynthesesDiversity Oriented SynthesisStereoselective SynthesisBiochemistryDiversity-oriented SynthesisAsymmetric SynthesisTotal SynthesisPharmacologyNatural Product SynthesisAsymmetric CatalysisEnantioselective SynthesisBiomolecular EngineeringNatural SciencesTaxol‐like Biological ActivityKey FragmentsNew ClassSynthetic Chemistry
Abstract Members of a new class of macrolide—the so‐called epothilones ( 1 )—showing a taxol‐like biological activity have recently been isolated. A convergent approach to 1 is presented, and the asymmetric syntheses of the three key intermediates 3, 4 , and 8 are reported.
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