Beilstein Journal of Organic Chemistry · 2011 · 37 citations · 16 references
EngineeringChemical EngineeringChemistryCatalysisProcess Systems EngineeringReaction EngineeringCatalytic Reaction EngineeringCatalytic Reactor DesignIndustrial CatalysisIndustrial Catalytic ProcessesPacked Bed ReactorsReaction Process DesignCatalyst Performance EvaluationCatalytic Process OptimizationCatalytic Reactor ModelingFlow-based High-throughput SynthesisHigh-throughput Reaction ScreeningHydrogenation ReactionsPacked Bed Reactor OptimizationReaction Engineering Of Catalytic Reactors
The performance of the ThalesNano H-Cube(®), a commercial packed bed flow hydrogenator, was evaluated in the context of small scale reaction screening and optimization. A model reaction, the reduction of styrene to ethylbenzene through a 10% Pd/C catalyst bed, was used to examine performance at various pressure settings, over sequential runs, and with commercial catalyst cartridges. In addition, the consistency of the hydrogen flow was indirectly measured by in-line UV spectroscopy. Finally, system contamination due to catalyst leaching, and the resolution of this issue, is described. The impact of these factors on the run-to-run reproducibility of the H-Cube(®) reactor for screening and reaction optimization is discussed.
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Carbons as supports for industrial precious metal catalysts
Emmanuel Auer, Andreas Freund, Jörg Pietsch et al. · Applied Catalysis A General · 1998 · 794 citations
A Microfluidic Device for Conducting Gas-Liquid-Solid Hydrogenation Reactions
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