Publication | Closed Access
Significance of antibody to DNA in systemic lupus erythematosus
100
Citations
16
References
1964
Year
ImmunohematologyComplement FixationImmunologyDiagnosisPathologyImmunophenotypingImmunotherapyAcute PhaseSerologic TestingAutoantibodiesMolecular DiagnosticsAutoimmune DiseaseSystemic Lupus ErythematosusSystemic Lupus Erythematosus TreatmentLupus NephritisDna ReplicationAutoimmunityImmunologic DiseaseAntibody ScreeningLupusAnti DnaMedicine
Abstract A study was made of serum antibody to DNA and nucleoprotein in 35 patients with SLE, using immunofluorescent spot techniques. Anti DNA was confirmed by complement fixation and observation of the “shaggy” nuclear fluorescent pattern. A striking correlation was observed between presence of anti DNA and the acute phase of SLE. Anti‐nucleoprotein, the most constant finding, showed only a general correlation of titer with phase of disease. Diagnostic and pathogenetic implications are discussed.
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