Arthritis & Rheumatism · 1964 · 100 citations · 16 references
Life SciencesImmunologyPathologyAutoimmunityClinical ImmunologyImmunopathologyAntibody CharacterizationAntigen Detection AssaysAutoantibodiesAutoimmune DiseasesDiagnostic ImmunologySystemic Lupus ErythematosusAnti-double-stranded Deoxyribonucleic Acid Antibody TestingAnti-double-stranded Dna AntibodiesAntinuclear Antibody PositivityComplement Fixation TestsCorrelationSerum BiomarkersSystemic Lupus Erythematosus AssociationsSystemic Lupus Erythematosus Diagnostics
Abstract A study was made of serum antibody to DNA and nucleoprotein in 35 patients with SLE, using immunofluorescent spot techniques. Anti DNA was confirmed by complement fixation and observation of the “shaggy” nuclear fluorescent pattern. A striking correlation was observed between presence of anti DNA and the acute phase of SLE. Anti‐nucleoprotein, the most constant finding, showed only a general correlation of titer with phase of disease. Diagnostic and pathogenetic implications are discussed.
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Complement Fixation with Cell Nuclei and DNA in Lupus Erythematosus
Wendye Robbins, Halsted R. Holman, H. Deicher et al. · Experimental Biology and Medicine · 1957 · 304 citations
Life Sciences, Immunology, Pathology +12