Concepedia

Foldamers as Dynamic Receptors: Probing the Mechanism of Molecular Association between Helical Oligomers and Rodlike Ligands This research was funded by the National Science Foundation (Grant CHE 00-91931). A.T. acknowledges the support of the Japan Society for the Promotion of Science in the form of a Fellowship for Japanese Junior Scientists. The authors gratefully acknowledge Dr. Petr Kuzmic for customizing his program Dynafit to facilitate our data analysis.

Aya Tanatani, Thomas Smart Hughes, Jeffrey S. Moore

Angewandte Chemie International Edition · 2002 · 124 citations · 14 references

Abstract

A dynamic binding mechanism allows the association of dumbbell-shaped ligand 2 with helical folded oligo(m-phenyleneethynylene)s 1 (see schematic representation). Association constants are oligomer length specific, with a maximum value for the icosamer and docosamer. These oligomers have helical conformations that are highly shape-complementary to 1; shorter and longer oligomers exhibit association constants roughly an order of magnitude smaller.