Electrophilic Cyclization of 2-(1-Alkynyl)-2-alken-1-ones Using the I₂/K₃PO₄ System: An Efficient Synthesis of Highly Substituted Iodofurans

Abstract

[reaction: see text] The electrophilic cyclization of 2-(1-alkynyl)-2-alken-1-ones in the presence of various alcohols or carbon-based nucleophiles offers an efficient and straightforward route to highly substituted iodofurans under extremely mild reaction conditions. The iodo derivatives are potential synthetic intermediates for amplification of molecular complexity.