Concepedia

Molecular Mechanism for Age-Related Memory Loss: The Histone-Binding Protein RbAp48

Elias Pavlopoulos, S. Jones, Stylianos Kosmidis, Maggie Close, Carla F. Kim, Olga Kovalerchik, Scott A. Small, Eric R. Kandel

Science Translational Medicine · 2013 · 108 citations · 45 references

DOIFull text

Open access

Abstract

A histone-binding protein that declines with age in the human dentate gyrus can reverse age-related memory deficits in mice.

References

45

Place navigation impaired in rats with hippocampal lesions

Richard Morris, Paul Garrud, J. N. P. Rawlins et al. · Nature · 1982 · 6.4K citations

, , +6

Phases of Aβ-deposition in the human brain and its relevance for the development of AD

Dietmar Rudolf Thal, Udo Rüb, M Orantes et al. · Neurology · 2002 · 3.3K citations

An anatomically comprehensive atlas of the adult human brain transcriptome

Michael Hawrylycz, Ed S. Lein, Angela Guillozet-Bongaarts et al. · Nature · 2012 · 3.2K citations · Full text

, , +11

Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

Heiko Braak, Irina Alafuzoff, Thomas Arzberger et al. · Acta Neuropathologica · 2006 · 3.1K citations · Full text

, , +20

Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

Teresa Gómez‐Isla, Joseph L. Price, Daniel W. McKeel et al. · Journal of Neuroscience · 1996 · 1.8K citations · Full text