Aluminum Chloride-Induced Heteroarylation of Arenes and Heteroarenes. 2. A New Synthesis of 4-Substituted Phthalazin-1(2<i>H</i>)-ones^,¹

Abstract

We herein report the efficient syntheses of 4-(hetero)aryl-substituted 1-chlorophthalazines via heteroarylation of arenes/heteroarenes through AlCl(3)-induced C[bond]C formation reactions. A number of (hetero)arenes were reacted with 1,4-dichlorophthalazine to give aryl/heteroaryl-substituted phthalazines in good to excellent yields. Many of them were converted to the corresponding phthalazin-1(2H)-ones.