Concepedia

INSM1: A Novel Immunohistochemical and Molecular Marker for Neuroendocrine and Neuroepithelial Neoplasms

Jason N. Rosenbaum, Zhenying Guo, Rebecca M. Baus, Helen Werner, William M. Rehrauer, Ricardo V. Lloyd

American Journal of Clinical Pathology · 2015 · 188 citations · 26 references

DOIFull text

Open access

Abstract

INSM1 expression was significantly increased in neoplastic vs nonneoplastic tissue. Furthermore, among midgut GI-NENs, neoplasms with known metastases showed significantly higher expression than those that had not yet metastasized.

References

26

Prediction of central nervous system embryonal tumour outcome based on gene expression

Scott L. Pomeroy, Pablo Tamayo, Michelle Gaasenbeek et al. · Nature · 2002 · 2.4K citations

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The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic β cells and intestinal endocrine cells

Mathias S. Gierl, Nikolaos Karoulias, Hagen Wende et al. · Genes & Development · 2006 · 216 citations · Full text

, , +16

Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis

Ayano Kawaguchi, Tomoko Ikawa, Takeya Kasukawa et al. · Development · 2008 · 191 citations · Full text

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IA1 is NGN3‐dependent and essential for differentiation of the endocrine pancreas

Georg Mellitzer, Stefan Bonné, Reini F. Luco et al. · The EMBO Journal · 2006 · 181 citations · Full text

A novel human insulinoma-associated cDNA, IA-1, encodes a protein with “zinc-finger” DNA-binding motifs.

Yasuhiro Gotô, M.G. De Silva, A Toscani et al. · Journal of Biological Chemistry · 1992 · 165 citations · Full text