Hemodynamics of Cerebral Aneurysms

TLDR

Cerebral aneurysm initiation and progression are degenerative arterial wall processes driven by complex interactions of biological and hemodynamic factors, with endothelial responses to blood flow patterns influencing tissue remodeling and abnormal flow combined with genetic predisposition leading to aneurysm formation. The study reviews recent advances in the basic mechanisms of aneurysm formation and evolution, emphasizing the role of hemodynamic patterns. It analyzes how hemodynamic patterns influence aneurysm development and progression.

Abstract

The initiation and progression of cerebral aneurysms are degenerative processes of the arterial wall driven by a complex interaction of biological and hemodynamic factors. Endothelial cells on the artery wall respond physiologically to blood-flow patterns. In normal conditions, these responses are associated with nonpathological tissue remodeling and adaptation. The combination of abnormal blood patterns and genetics predisposition could lead to the pathological formation of aneurysms. Here, we review recent progress on the basic mechanisms of aneurysm formation and evolution, with a focus on the role of hemodynamic patterns.