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Publication | Open Access

Efficacy and Antivascular Effects of EphA2 Reduction With an Agonistic Antibody in Ovarian Cancer

DOIFull Paper Access

133

Citations

52

References

2006

Year

Charles N. Landen, Chunhua Lu, Liz Y. Han, Karen Coffman, Elizabeth Bruckheimer, Jyotsnabaran Halder, Lingegowda S. Mangala, William M. Merritt, Yvonne G. Lin, Changhou Gao,
JNCI Journal of the National Cancer Institute

Abstract

EA5 in combination with paclitaxel decreased tumor growth in an orthotopic ovarian cancer mouse model through antiangiogenic mechanisms associated with reduced levels of VEGF and phosphorylated Src. Humanized antibody constructs against EphA2 are worthy of future study.

References

YearCitations

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