Circulating levels of matrix metalloproteinases MMP‐3 and MMP‐2 in renal transplant recipients with chronic transplant nephropathy

Abstract

Serum proMMP-2 and proMMP-3 reflect the changes of glomerular and interstitial extracellular matrix in chronic transplant nephropathy, suggesting that they could play a role in the pathogenesis of this condition. Acute rejection is associated with increased levels of proMMP-1, which could be a reflection of the stimulation induced by a number of inflammatory cytokines produced in such a process.