In Vitro Equivalence Studies of Generic Metformin Hydrochloride Tablets and Propranolol Hydrochloride Tablets Under Biowaiver Conditions in Lagos State, Nigeria

Abstract

This study used biowaiver conditions to assess bioequivalence of some generic products used in Nigeria. None of the generic samples tested met biowaiver conditions; therefore, in vivo bioequivalence studies are required to ascertain therapeutic equivalence. To take advantage of the cost savings of using in vitro dissolution as a surrogate for bioequivalence studies, manufacturers of generic products need to consider factors that affect solubility and permeability of their products when formulating them.