Angewandte Chemie International Edition · 2011 · 80 citations · 61 references
Natural SciencesChemistryCatalysisAlkyne ComplexesCatalyst DesignChiral SeparationHeterocycle SynthesisMacrocycle SynthesisOrganic SynthesisAsymmetric Heterocycle SynthesisChiral Product SynthesisEnantioselective CatalysisEnantioselective SynthesisEnantioselectivityIntramolecular CatalysisPalladium CatalystsRoom-temperature Synthesis
A long-awaited asymmetric version of the intramolecular hydroarylation of alkynes to form fused ring systems has been developed. A cationic palladium(II)/(S)-xyl-H8-binap complex was used to catalyze an enantioselective hydroarylation of alkynes at room temperature to furnish axially chiral 4-aryl 2-quinolinone derivatives in good yields with good enantioselectivity (see scheme; Bn=benzyl).
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Atroposelective Synthesis of Axially Chiral Biaryl Compounds
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