PubMed · 2004 · 12 citations · 7 references
MedicineOncologyPathologyGastrointestinal OncologyMetastasisNeoplasiaColonic DiseasesColorectal CancerGastric CancerGastrointestinal NeoplasmsGastrointestinal PathologyMetastatic Gastrointestinal CancerColonic AdenocarcinomaColonic PathologyGastrointestinal MalignancyGastrointestinal TumorsHistologic ExaminationInitial BiopsyLower Abdominal PainSubmucosal Biopsy
A 68-year-old Japanese man with a history of linitis plastica carcinoma of the stomach and subsequent gastrectomy 8 years previously presented with lower abdominal pain. Radiological and endoscopic examinations showed multiple submucosal nodular lesions similar to Crohn's disease in the ileocecal area. A firm diagnosis could not be made after initial multiple biopsies. Finally, a submucosal biopsy revealed adenocarcinoma. The ileocecal lesion was diagnosed as a recurrence because of the histological findings, which included mucosal preservation, a similarity with the histologic type of stomach carcinoma, and atypical immunoreactivity for primary colon carcinoma; the lesion was negative for both cytokeratin 7 and cytokeratin 20. In cases where metastatic carcinoma of the colon is suspected, we recommend early consideration of a submucosal biopsy.
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Endoscopic therapy for early colon cancer: the strip biopsy resection technique
Mikio Karita, Masahiro Tada, Kiwamu Okita et al. · Gastrointestinal Endoscopy · 1991 · 200 citations
Primary and metastatic scirrhous carcinoma of the rectum
EJ Balthazar · Medical Entomology and Zoology · 1979 · 56 citations