Journal of Antimicrobial Chemotherapy · 1978 · 68 citations · 0 references
Life SciencesInfectious DiseasesMicrobiologyAntimicrobial PharmacotherapyAntimicrobial ResistanceMedical MicrobiologyAntibacterial PharmacologyAntibiotic ResistanceAntimicrobial TherapyBacterial InfectionsResistance In Gram-negative BacteriaResistance In Gram-positive BacteriaAntimicrobial ChemotherapyAntimicrobial Drug DevelopmentBacteriostatic ActivityBacteriostatic AgentsBacteroides SpeciesCephalosporin TherapyPseudomonas Aeruginosa Resistance
The activity of HR 756 was compared with other cephalosporins and cefoxitin. Three groups of organisms which may present particular problems in antibiotic chemotherapy were selected for study. HR 756 was the most potent compound against H. influenzae; β-lacactamase producing strains were also susceptible. Bacteroides fragilis strains were less susceptible to HR 756 than cefoxitin. Against Gram-negative rods HR 756 displayed very high activity particularly towards Klebsiella and Providencia spp. The activity against Pseudomonas aeruginosa was also notable, the majority of strains being inhibited by 16 μg/ml.