Acetyl cholinesterase inhibition potential and antioxidant activities of ferulic acid isolated from Impatiens bicolor Linn.

Abstract

Ferulic acid was isolated from ethyl acetate extract of Impatiens bicolor Linn. and identified by X-ray analysis. The acetylcholine esterase inhibition, radical scavenging activity (DPPH scavenging assay) and FRAP assay were carried out on the compound. It was found that the effect of ferulic acid was strongly dose dependent i.e., 25 - 175 µg/ml in DPPH assay, 50 - 150 µg/ml in FRAP assay and 50 - 200 µg/ml in acetylcholine esterase inhibition assay. However, ferulic acid did not show significant change in acetylcholine esterase inhibition and antioxidant activity at high concentration.   Key words: Acetyl cholinesterase, FRAP, ferulic acid, Impatiens bicolor,medicinal plant.