Concepedia

Relationship Between <i>MYCN</i> Copy Number and Expression in Rhabdomyosarcomas and Correlation With Adverse Prognosis in the Alveolar Subtype

Daniel Williamson, Yong‐Jie Lu, Tony Gordon, Raf Sciot, Anna Kelsey, Cyril Fisher, Christopher Poremba, John Anderson, Kathy Pritchard‐Jones, Janet Shipley

Journal of Clinical Oncology · 2005 · 126 citations · 24 references

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Abstract

MYCN deregulation is a feature of rhabdomyosarcoma tumorigenesis, defines groups of patients with a poor prognosis, and is a potential target for novel therapies.

References

24

Intergroup Rhabdomyosarcoma Study-IV: Results for Patients With Nonmetastatic Disease

William M. Crist, James R. Anderson, Jane L. Meza et al. · Journal of Clinical Oncology · 2001 · 1.1K citations

Transposition and amplification of oncogene-related sequences in human neuroblastomas

Nancy E. Kohl, Naotoshi Kanda, Rhona Schreck et al. · Cell · 1983 · 728 citations

, , +3

N-<i>myc</i> is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

Paul S. Knoepfler, Pei Cheng, Robert N. Eisenman · Genes & Development · 2002 · 504 citations · Full text

, , +24

Expression and amplification of the N-myc gene in primary retinoblastoma

Wen‐Hwa Lee, A. Linn Murphree, William F. Benedict · Nature · 1984 · 450 citations

, , +8

Human small-cell lung cancers show amplification and expression of the N-myc gene.

Marion M. Nau, Burke J. Brooks, D N Carney et al. · Proceedings of the National Academy of Sciences · 1986 · 293 citations · Full text

, , +16