Concepedia

Aerobic Oxidative Kinetic Resolution of Racemic Secondary Alcohols with Chiral Bifunctional Amido Complexes

S. Arita, Takashi Koike, Yoshihito Kayaki, Takao Ikariya

Angewandte Chemie International Edition · 2008 · 169 citations · 37 references

DOI

Concepts

Abstract

Up for air: The aerobic oxidative kinetic resolution of racemic secondary alcohols with chiral bifunctional Ir, Rh, and Ru catalysts proceeds smoothly under mild conditions to provide chiral alcohols with up to 99 % ee, and O2 serves as an excellent hydrogen acceptor.

References

37

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Metal−Ligand Bifunctional Catalysis:  A Nonclassical Mechanism for Asymmetric Hydrogen Transfer between Alcohols and Carbonyl Compounds

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Kinetic resolution of racemic allylic alcohols by enantioselective epoxidation. A route to substances of absolute enantiomeric purity?

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Bifunctional transition metal-based molecular catalysts for asymmetric syntheses

Takao Ikariya, Kunihiko Murata, Ryōji Noyori · Organic & Biomolecular Chemistry · 2005 · 636 citations

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