Chronic atrial fibrillation up-regulates β1-Adrenoceptors affecting repolarizing currents and action potential duration

Abstract

The present results demonstrate that CAF increases the effects of β1-Adrenoceptor stimulation on repolarizing currents by means of a chamber-specific up-regulation of the receptors. This, together with the ion channel derangements produced by CAF, could contribute to the long-term stabilization of the arrhythmia by shortening the AP duration.