In Vivo Imaging of the Glucagonlike Peptide 1 Receptor in the Pancreas with ⁶⁸Ga-Labeled DO3A-Exendin-4

Abstract

These results strongly support the notion that (68)Ga-DO3A-exendin-4 uptake in the pancreas is mediated by specific receptor binding. In addition, pancreatic uptake was decreased by selective destruction of β-cells. This result suggests that GLP-1R can be quantified in vivo, which has major implications for the prospect of imaging of native β-cells.