Structural and Energetic Consequences of Mutations in a Solvated Hydrophobic Cavity

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Axel T. Brünger, Paul D. Adams, G. Marius Clore et al. · Acta Crystallographica Section D Biological Crystallography · 1998 · 15.8K citations

Natural Sciences, Biophysics, Chemistry +17

Improved methods for building protein models in electron density maps and the location of errors in these models

T. Alwyn Jones, Jin-yu Zou, Sandra W. Cowan et al. · Acta Crystallographica Section A Foundations of Crystallography · 1991 · 12.7K citations

Life Sciences, Biochemistry, Biomolecular Modeling +16

Anatomy of protein pockets and cavities: Measurement of binding site geometry and implications for ligand design

Jie Liang, Clare Woodward, Herbert Edelsbrunner · Protein Science · 1998 · 1.1K citations · Full text

Life Sciences, Biochemistry, Bioinformatics +17

Response of a Protein Structure to Cavity-Creating Mutations and Its Relation to the Hydrophobic Effect

A.E. Sauer-Eriksson, W.A. Baase, X. J. Zhang et al. · Science · 1992 · 945 citations · Full text

Life Sciences, Biochemistry, Biophysics +15

Hydrophobic bonding and accessible surface area in proteins

Cyrus Chothia · Nature · 1974 · 894 citations

Life Sciences, Biochemistry, Biophysics +13