FEBS Letters · 1997 · 206 citations · 14 references
Life SciencesNeurosciencePharmacologyMolecular NeuroscienceNeuroendocrinologyNeuropharmacologyG Protein-coupled Receptor SignalingHormone ReceptorsHormone SignalingNeurotransmitter ReceptorsReceptor PharmacologyReceptor PhysiologyCloningG Protein-coupled Hormone ReceptorsG Protein-coupled Neuropeptide ReceptorsG Protein-coupled Receptor Structure-function RelationshipsNeuropeptide Receptor SignalingNeuropeptide Receptor SubtypesPeptide Hormone ReceptorsReceptor-g Protein Coupling
Galanin (GAL) is a widely distributed neuropeptide with diverse biological effects including modulation of hormone release, antinociception and modification of feeding behavior. Its effects are mediated through G-protein-coupled receptors (GPCR) for which only a single type has been cloned, GAL receptor 1 (GALR1). We describe the cloning of a second galanin receptor type, GALR2, from rat hypothalamus. The GALR2 amino acid sequence is 38% identical to GALR1 and is pharmacologically similar to GALR1 when expressed in COS-7 cells. GALR2 is encoded by a single gene containing at least one intron and expressed in a diverse range of tissues.
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Galanin — a novel biologically active peptide from porcine intestine
Kazuhiko Tatemoto, Åke Rökaeus, Hans Jörnvall et al. · FEBS Letters · 1983 · 1.5K citations · Full text
Distribution of a rat galanin receptor mRNA in rat brain
Eric L. Gustafson, Kelli E. Smith, Margaret M. Durkin et al. · Neuroreport · 1996 · 144 citations