Journal of Applied Polymer Science · 1990 · 310 citations · 7 references
Natural SciencesMaterials SciencePharmaceuticsDrug DeliveryPolymer ChemistryPolymer MaterialsBiodegradable PolymersBiodegradationDrug Delivery BiomaterialsPolymeric BiomaterialsPolymeric Carrier SystemsPolymeric Drug Delivery SystemsBiodegradable Polymer CarriersBiomedical ApplicationsBulk PolymerizationDrug Release MechanismsPoly(glycolic Acid)Polylactide SynthesisPolymer Composition EffectsPolymers In Drug Formulation
Abstract Polylactide (PLA)‐poly(ethylene glycol) (PEG) copolymers were synthesized from polyethylene glycol and D , L ‐lactide using low toxic stannous octoate as catalyst at 180°C by bulk polymerization. The copolymers were characterized by GPC, IR, and 13 C‐NMR. A full assignment NMR spectrum is presented. The physical, drug release, and biodegradable properties in vitro of PLA–PEG copolymers were investigated. The result indicates that the rates of drug release and biodegradation could be tailored by adjusting polymer composition. This amorphous material might be used as a drug carrier in medical applications.
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Biodegradable poly(lactic acid) polymers
R. K. Kulkarni, Evan G. Moore, Andrew F. Hegyeli et al. · Journal of Biomedical Materials Research · 1971 · 798 citations