Intraspecies Signaling Involving the Diffusible Signal Factor BDSF ( <i>cis</i> -2-Dodecenoic Acid) Influences Virulence in <i>Burkholderia cenocepacia</i>

Abstract

Burkholderia cenocepacia produces a diffusible fatty acid signal molecule, cis-2-dodecenoic acid (BDSF), that has been implicated in interspecies and interkingdom communication. Here, we show that BDSF also acts as an intraspecies signal in B. cenocepacia to control factors contributing to virulence of this major opportunistic pathogen.