Results of Surgical Salvage After Failure of Definitive Radiation Therapy for Early-Stage Squamous Cell Carcinoma of the Glottic Larynx

Abstract

Careful selection of patients with early-stage glottic tumors that recur or progress after radiation allows patients to be successfully treated by partial laryngectomy with excellent survival outcome. However, despite an aggressive policy of performing partial laryngectomy when feasible, up to 50% of patients will require a total laryngectomy owing to progression of disease. These patients have poorer survival outcomes manifested by local, regional, and distant disease progression.