Effects of pranlukast, a cysteinyl leukotriene receptor 1 antagonist, combined with inhaled beclomethasone in patients with moderateor severe asthma

Leukotrienes are potent constrictors of human bronchi

Sven‐Erik Dahlén, Per Hedqvist, Sven Hammarström et al. · Nature · 1980 · 972 citations

Medicine, Pharmacology, Physiology +11

Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro.

Zvi Marom, James H. Shelhamer, M K Bach et al. · PubMed · 1982 · 417 citations

Life Sciences, Immunology, Pharmacology +10

Inhibition of Exercise-Induced Bronchoconstriction by MK-571, a Potent Leukotriene D₄–Receptor Antagonist

Patrick Manning, Richard M. Watson, Dorothy J. Margolskee et al. · New England Journal of Medicine · 1990 · 401 citations · Full text

Life Sciences, Pharmacology, Exercise Physiology +8

Montelukast Added to Inhaled Beclomethasone in Treatment of Asthma

Michel Laviolette, Kerstin Malmström, Susan Lu et al. · American Journal of Respiratory and Critical Care Medicine · 1999 · 353 citations

Pharmacy, Pharmacology, Pharmacotherapy +17

Effects of 6 Weeks of Therapy with Oral Doses of ICI 204,219, a Leukotriene D4 Receptor Antagonist, in Subjects with Bronchial Asthma. ACCOLATE Asthma Trialists Group

S L Spector, Lewis J. Smith, Mitchell Glass · American Journal of Respiratory and Critical Care Medicine · 1994 · 348 citations

Pharmacy, Pharmacology, Pharmacotherapy +11