Epicutaneous sensitization with <i>Dermatophagoides farinae</i> induces generalized allergic dermatitis and elevated mite‐specific immunoglobulin E levels in a canine model of atopic dermatitis

Abstract

This study demonstrated that epicutaneous application of HDM slurry to MAB dogs results in elevations of HDM-specific IgE, localized and generalized pruritic dermatitis resembling spontaneous canine AD, and histologic changes typical of IgE-driven inflammation. We feel that these results suggest that epicutaneous exposure to allergen may play an important role during both the sensitization and the perpetuation of AD, and provide support for the use of a canine model in the investigation of the pathogenesis of AD.