Effects of Ketamine on Contraction and Synthesis of Inositol 1,4,5-Trisphosphate in Smooth Muscle of the Rabbit Mesenteric Artery

Abstract

These results indicate that, in the rabbit mesenteric artery, ketamine inhibits agonist-induced Ca2+ release through its inhibitory action on the agonist-induced synthesis of InsP3. Thus, it is possible that ketamine interferes with the synthesis of intracellular second messengers.