Abnormally expressed ER stress response chaperone Gp96 in CD favours adherent-invasive <i>Escherichia coli</i> invasion

Abstract

Gp96 is overexpressed on the apical surface of ileal epithelial cells in patients with CD and acts as a host cell receptor for OMVs, promoting AIEC invasion. From the results shown here, it is speculated that AIEC could take advantage of the abnormal expression of Gp96 in patients with CD to invade the ileal mucosa.