Palladium‐Catalyzed Dehydrogenative β′‐Arylation of β‐Keto Esters under Aerobic Conditions: Interplay of Metal and Brønsted Acids

Abstract

The Brønsted aids: The first dehydrogenative arylation of β-keto esters with arenes under ambient aerobic conditions is described. Under a Pd(II)/Brønsted acid co-catalytic system, regioselective arylations with alkoxylated arenes and phenols were achieved in good yields, even in gram-scale conditions.