Brain Research · 1997 · 275 citations · 27 references
MedicineNeurobiologyNeuroscienceDementiaMolecular NeuroscienceNeuropharmacologyNeurodegenerative DiseasesNeurodegenerative DisordersNeuroprotectionNeurotoxicity MechanismsExcitotoxicity InhibitionFree Radical ScavengingNeuroprotective AgentsNeuroprotective AntioxidantsNmda Receptor SignalingNmda Receptors
Several lines of evidence suggest that 17beta-estradiol (betaE2) has neuroprotective properties. The risk and severity of dementia are decreased in women who have received estrogen therapy, and betaE2 protects neurons in vitro against death from a variety of stressors. Neuroprotection by betaE2 has been suggested to be due to free radical scavenging. We demonstrate an additional neuroprotective mechanism whereby betaE2 protects against NMDA-induced neuronal death by directly inhibiting the NMDA receptor.
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Blockade of <i>N</i> -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain
R. P. Simon, J. H. Swan, T. Griffiths et al. · Science · 1984 · 1.7K citations