Berkeleydione and Berkeleytrione, New Bioactive Metabolites from an Acid Mine Organism.

Abstract

Two novel hybrid polyketide-terpenoid metabolites were isolated from a <i>Penicillium</i> sp. growing in the Berkeley Pit Lake of Butte, Montana.\nTheir structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (<b>1</b>). Both compounds\ninhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell\nline antitumor screen.