Enantioselective CH Amination Using Cationic Ruthenium(II)–pybox Catalysts

Abstract

The whole “pybox” and dice: Highly enantioselective amination reactions of both allylic and benzylic CH bonds are catalyzed by cationic ruthenium(II)–pybox complexes (see structure). A novel mode of stereocontrol, which is induced by the versatile pybox ligand, is proposed to account for the excellent enantioselectivity in these reactions. Boc=tert-butoxycarbonyl, pybox=pyridine bisoxazoline.